Immunopharmacological Approach of Carvedilol in Chronic Chagas Heart Disease

نویسندگان

  • Carla Paixão Miranda
  • Fernando Antônio Botoni
  • Manoel Otávio da Costa Rocha
چکیده

Correspondência: Carla Paixão Miranda • Rua Lindolfo Garcia, Alto do Córrego. CEP 38600-000, Paracatu, MG – Brasil E-mail: [email protected]; [email protected] Artigo recebido em 20/06/14; revisado em 15/08/14; aceito em 15/08/14. Palavras-chave Cardiomiopatia Chagásica; Adenosina Desaminase/ efeitos de drogas; Antioxidantes; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Carvedilol Enhances the Antioxidant Effect of Vitamins E and C in Chronic Chagas Heart Disease

BACKGROUND Chagas disease is still an important endemic disease in Brazil, and the cardiac involvement is its more severe manifestation. OBJECTIVE To verify whether the concomitant use of carvedilol will enhance the antioxidant effect of vitamins E and C in reducing the systemic oxidative stress in chronic Chagas heart disease. METHODS A total of 42 patients with Chagas heart disease were s...

متن کامل

Autonomic dysfunction and beta blocker therapy in Chagas heart disease

In a hamster model of Chagas disease, Pimentel et al. (1) recently found that 1) carvedilol decreased mortality in the acute, but not in the chronic stage and 2) in the chronic stage, carvedilol neither changed the left ventricular diameter and/or function, nor attenuated changes in the resting electrocardiogram (ECG), nor decreased the myocardial collagen content. In contrast, we did not obser...

متن کامل

The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy

OBJECTIVE Chagas' disease has spread throughout Latin America because of the high rate of migration among these countries. Approximately 30% of Chagas' patients will develop cardiomyopathy, and 10% of these will develop severe cardiac damage leading to heart failure. Beta-blockade improves symptoms and survival in heart failure patients; however, its efficacy has not been well established in Ch...

متن کامل

Effects of carvedilol on left ventricular remodelling in chronic stable heart failure: a cardiovascular magnetic resonance study.

BACKGROUND The ability of beta blockers to improve left ventricular function has been demonstrated, but data on the effects on cardiac remodelling are limited. OBJECTIVE To investigate, using cardiovascular magnetic resonance (CMR), the effects of carvedilol on left ventricular remodelling in patients with chronic stable heart failure and left ventricular systolic dysfunction caused by corona...

متن کامل

CARDIOVASCULAR MEDICINE Effects of carvedilol on left ventricular remodelling in chronic stable heart failure: a cardiovascular magnetic resonance study

Background: The ability of b blockers to improve left ventricular function has been demonstrated, but data on the effects on cardiac remodelling are limited. Objective: To investigate, using cardiovascular magnetic resonance (CMR), the effects of carvedilol on left ventricular remodelling in patients with chronic stable heart failure and left ventricular systolic dysfunction caused by coronary ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 103  شماره 

صفحات  -

تاریخ انتشار 2014